Varenicline has antidepressant-like activity in the forced swim test and augments sertraline's effect
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Antidepressant-like effect of nicotinamide adenine dinucleotide in the forced swim test in rats.
Nicotinamide adenine dinucleotide (NADH), a cosubstrate for energy transfer in the oxidative phosphorylation, has supposedly beneficial effects on central nervous system (CNS)-related diseases, e.g., shown in an open study with depressive patients. To our knowledge there are no data concerning the efficacy of NADH in animal tests. Acute effects of NADH and the precursor nicotinamide, compared t...
متن کاملInvolvement of NMDA and AMPA receptors in the antidepressant-like activity of antidepressant drugs in the forced swim test.
BACKGROUND The involvement of glutamate system (particularly the NMDA and AMPA receptors) in the mechanism of antidepressant activity was demonstrated in preclinical and clinical studies. METHODS In the present study, we investigated the effect of NMDA and AMPA receptors' ligands (agonists and antagonists) on the antidepressant-like activity of escitalopram, milnacipran, imipramine and reboxe...
متن کاملAntidepressant-like effects of baclofen and LY367385 in the forced swim test in rats.
Baclofen, an agonist of GABA(B) receptors and LY367385, an antagonist of mGluR(1a) receptors, given alone or jointly, reduced the immobility time in the forced swim test but only their separate administration enhanced motility in group of rats without hypoxia. Short-term hypoxia (2% O2, 98% N2, 4 min) did not change the activity of the rats in the forced swim test and it did robustly decrease t...
متن کاملNMDA and AMPA receptors are involved in the antidepressant-like activity of tianeptine in the forced swim test in mice.
It is known that tianeptine exhibits antidepressant-like activity. Its influence on the glutamatergic system is also known, but the mechanisms involved in this activity remain to be established. The aim of this study was to investigate the involvement of the glutamate pathway in the antidepressant-like action of tianeptine. We investigated the effects of N-methyl-D-aspartate (NMDA) and α-amino-...
متن کاملAntidepressant-Like Effects of -Opioid Receptor Antagonists in the Forced Swim Test in Rats
We showed previously that cAMP response element-binding protein (CREB) within the nucleus accumbens (NAc) of rats regulates immobility in the forced swim test (FST), an assay used to study depression. Because CREB regulates expression of dynorphin (which acts at -opioid receptors) in NAc neurons, these findings raised the possibility that -receptors mediate immobility behaviors in the FST. Here...
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ژورنال
عنوان ژورنال: European Journal of Pharmacology
سال: 2009
ISSN: 0014-2999
DOI: 10.1016/j.ejphar.2009.01.002